k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design
نویسندگان
چکیده
منابع مشابه
k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design
Computational strain design protocols aim at the system-wide identification of intervention strategies for the enhanced production of biochemicals in microorganisms. Existing approaches relying solely on stoichiometry and rudimentary constraint-based regulation overlook the effects of metabolite concentrations and substrate-level enzyme regulation while identifying metabolic interventions. In t...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003487